Targeting prostate cancer metabolism | Mirage News

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South Australian medical researchers have identified how prostate cancer cells use glucose to grow and survive, which in turn could be the secret to destroying them.

In a new study published in the international journal eLife, researchers at Flinders University and The University of Adelaide used cutting-edge technologies to analyse this metabolic pathway in prostate cancer cells, in the process demonstrating that it represents a weakness in tumours that could be exploited to develop new therapies.

Associate Professor Luke Selth from the Flinders Health and Medical Research Institute (FHMRI) and Freemasons Centre for Male Health and Wellbeing (FCMHW) says

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Lipocalin-2: Structure, function, distribution and role in metabolic disorders

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This article was originally published here

Biomed Pharmacother. 2021 Aug 27;142:112002. doi: 10.1016/j.biopha.2021.112002. Online ahead of print.

ABSTRACT

Lipocalin-2 (LCN-2) is a novel, 198 amino acid adipocytokine also referred to as neutrophil gelatinase-associated lipocalin (NGAL). LCN-2 is a circulatory protein responsible for the transportation of small and hydrophobic molecules (steroid, free fatty acids, prostaglandins and hormones) to target organs after binding to megalin/glycoprotein and GP330 SLC22A17 or 24p3R LCN-2 receptors. LCN-2 has been used as a biomarker for acute and chronic renal injury. It is present in a large variety of cells including neutrophil, hepatocytes, lung, bone marrow, adipose tissue,

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Best at-home metabolism tests of 2021

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Metabolic tests look at a person’s hormone levels or output of carbon dioxide and oxygen. They can also indicate a hormone imbalance or help an individual with their weight goals. Several companies offer metabolic tests for home use that people can purchase online.

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A metabolism test measures the rate at which the body uses oxygen or burns calories. It can provide an estimation of how many calories a person burns when

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Role of Microenvironmental and Metabolic Factors during Anti-infectious Immune Responses

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From January 2022 onwards, the German Research Foundation (DFG) is funding a new research training group (RTG) at FAU and the University Hospital Erlangen which will investigate the impact of micro-milieu factors on the antimicrobial defense and survival of infectious agents in tissues.

Why are many infections caused by bacteria, fungi or parasites successfully combated by the immune system, but not others? What role do the individual cells of the immune system play in interaction with the microenvironment in the tissue, the milieu factors as well as the metabolism of the infected cells and the pathogens? How does this “immunomicrotope”

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Understanding and targeting prostate cancer metabolism

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Understanding and targeting prostate cancer metabolism
(A) Two distinct AR siRNAs (siAR (1) and siAR (2); 12.5 nM) reduce the expression of 6PGD at the protein level in LNCaP cells. Cells were transfected with 12.5 nM of each siRNA; after 48 h, proteins were extracted and assessed by Western blotting. (B) siAR (2) reduces the expression of 6PGD mRNA in LNCaP cells. Transfection of siRNAs was performed as in A. Differential expression was evaluated using an unpaired t test (**, p

South Australian medical researchers have identified a new way in which prostate cancer cells use glucose to grow and survive, which in turn could be

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