Engineering CAR T cells to deliver endogenous RNA wakes solid tumors to respond to therapy

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Engineering CAR T cells to deliver endogenous RNA wakes solid tumors to respond to therapy
Image of a CAR T cell. Credit: Penn Medicine

Chimeric antigen receptor (CAR) T cell therapy, which uses engineered T cells to treat certain types of cancers, has often been a challenging approach to treating solid tumors. CAR T cells need to recognize a specific target on cancer cells to kill them. However, cancer cells do not always have the target, or they find ways to hide the target and stay invisible to CAR T cell attack. A new study from Penn Medicine, published online in Cell, demonstrates that RN7SL1, a naturally occurring RNA, can activate the body’s own

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Atrium Health Navicent offers COVID monoclonal antibody therapy

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The treatment, which is given via IV and may prevent COVID symptoms from worsening, is available with a physician’s referral

MACON, Ga. — Atrium Health Navicent is now offering outpatient COVID-19 monoclonal antibody treatments at five Central Georgia locations.

According to a release from Atrium Health, if administered within the first week of COVID-19 symptoms, the treatment is effective in neutralizing the virus and preventing symptoms from worsening.

The treatment is administered via IV, delivering medication directly into the patient’s bloodstream.

It’s intended for people who have recently tested positive for COVID-19, are at high risk for developing severe illness,

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Jon Hopkins announces new album ‘Music For Psychedelic Therapy’ | News | Domino

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Jon Hopkins announces his new album, Music For Psychedelic Therapy, out November 12th (digitally/CD) and February 11th (LP)  on Domino. Today, he presents the album closer, “Sit Around The Fire,” a unique collaboration between Hopkins, producer and ceremony guide East Forest and legendary guru, the late Ram Dass

Music for Psychedelic Therapy is Hopkins’ first full-length since sister albums, the GRAMMY-nominated Singularity (2018), “a beat-music odyssey that thrums with spiritual resonance” (Pitchfork) and Immunity (2013). For this collection, Hopkins wanted to make something that faced the opposite direction, something egoless and introspective, made with total,

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Mesoblast’s COVID-19 Respiratory Therapy Hits Another Snag on Route to Potential EUA

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Shares in  Mesoblast dropped on the last day of August 2021 after the Melbourne-based biotech was told that its investigational respiratory treatment for COVID-19 needs to undergo another trial in order to receive emergency use authorization (EUA) from U.S. Food and Drug Administration (FDA). 

In its 2021 full year financial results, the company stated that it met with the U.S. Food & Drug Administration in June as it sought an EUA designation for remestemcel-L (Ryoncil). The drug is intended to treat COVID-19 patients who suffer from moderate or severe acute respiratory distress syndrome (ARDS) and are dependent on

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Could gene therapies be used to cure more people with HIV?

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Medical science is starting to license and use drugs and procedures that change the genetic code inside the body’s cells, and to correct the ‘bad code’ that can give rise to conditions such as cancer and the auto-immune diseases. Since HIV is a disease that results from a virus inserting such a piece of bad code into our genes, such therapies could be used to snip out that code and effect a cure.

This was what attendees at last month’s International AIDS Society Conference on HIV Science (IAS 2021) heard at the workshop on curing HIV. The workshop

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